Hyaluronan-binding protein 2

Definition:

Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. May function as a tumor suppressor negatively regulating cell proliferation and cell migration.

References:

[1]. N H Choi-Miura, et al. Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator. J Biochem. 1996 Jun;119(6):1157-65. [Content Brief]

[2]. J Römisch, et al. The FVII activating protease cleaves single-chain plasminogen activators. Haemostasis. 1999;29(5):292-9. [Content Brief]

[3]. N H Choi-Miura, et al. Identification of the substrates for plasma hyaluronan binding protein. Biol Pharm Bull. 2001 Feb;24(2):140-3. [Content Brief]

[4]. Sudheer Kumar Gara, et al. Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer. N Engl J Med. 2015 Jul 30;373(5):448-55. [Content Brief]

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