Immunoglobulin-binding protein 1

Definition:

Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.

References:

[1]. Li Jiang, et al. Structural basis of protein phosphatase 2A stable latency. Nat Commun. 2013;4:1699. [Content Brief]

[2]. Mei Kong, et al. Alpha4 is an essential regulator of PP2A phosphatase activity. Mol Cell. 2009 Oct 9;36(1):51-60. [Content Brief]

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