Inactive caspase-12
Definition:
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
References:
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[1]. Heinz Fischer, et al. Human caspase 12 has acquired deleterious mutations. Biochem Biophys Res Commun. 2002 May 3;293(2):722-6. [Content Brief]
[2]. Maya Saleh, et al. Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature. 2004 May 6;429(6987):75-9. [Content Brief]
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