Inosine-5'-monophosphate dehydrogenase 2

Definition:

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

References:

[1]. S F Carr, et al. Characterization of human type I and type II IMP dehydrogenases. J Biol Chem. 1993 Dec 25;268(36):27286-90. [Content Brief]

[2]. Jeremy E McLean, et al. Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo. Biochem J. 2004 Apr 15;379(Pt 2):243-51. [Content Brief]

[3]. P W Hager, et al. Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding. Biochem Pharmacol. 1995 May 11;49(9):1323-9. [Content Brief]

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