Insulin-induced gene 2 protein
Definition:
References:
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[1]. Daqian Xu, et al. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature. 2020 Apr;580(7804):530-535. [Content Brief]
[2]. Yi Gong, et al. Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6154-9. [Content Brief]
[3]. Ruobing Ren, et al. PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels. Science. 2015 Jul 10;349(6244):187-91. [Content Brief]
[4]. Youngah Jo, et al. Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20503-8. [Content Brief]
[5]. Arun Radhakrishnan, et al. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6511-8. [Content Brief]
[6]. Daisuke Yabe, et al. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12753-8. [Content Brief]
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