Integrator complex subunit 13

Definition:

Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

References:

[1]. Laura A Lee, et al. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Dev Cell. 2005 Mar;8(3):435-42. [Content Brief]

[2]. Jeanne N Jodoin, et al. Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. Mol Biol Cell. 2012 Dec;23(24):4713-24. [Content Brief]

[3]. Jeanne N Jodoin, et al. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Mol Biol Cell. 2013 Sep;24(18):2954-65. [Content Brief]

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