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Integrator complex subunit 6

Definition:

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.

References:

[1]. Ilse Wieland, et al. Ectopic expression of DICE1 suppresses tumor cell growth. Oncol Rep. 2004 Aug;12(2):207-11. [Content Brief]

[2]. Jeanne N Jodoin, et al. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Mol Biol Cell. 2013 Sep;24(18):2954-65. [Content Brief]

[3]. David Baillat, et al. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell. 2005 Oct 21;123(2):265-76. [Content Brief]

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