Integrin-linked kinase-associated serine/threonine phosphatase 2C

Definition:

Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.

References:

[1]. Ashu S Kumar, et al. ILKAP regulates ILK signaling and inhibits anchorage-independent growth. Oncogene. 2004 Apr 22;23(19):3454-61. [Content Brief]

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