Intercellular adhesion molecule 1

Definition:

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.; (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.; (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.; (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.

References:

[1]. J M Greve, et al. The major human rhinovirus receptor is ICAM-1. Cell. 1989 Mar 10;56(5):839-47. [Content Brief]

[2]. T Hayashi, et al. MUC1 mucin core protein binds to the domain 1 of ICAM-1. Digestion. 2001;63 Suppl 1:87-92. [Content Brief]

[3]. C Xiao, et al. Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1. J Virol. 2001 Mar;75(5):2444-51. [Content Brief]

[4]. Chuan Xiao, et al. The crystal structure of coxsackievirus A21 and its interaction with ICAM-1. Structure. 2005 Jul;13(7):1019-33. [Content Brief]

[5]. S D Marlin, et al. A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection. Nature. 1990 Mar 1;344(6261):70-2. [Content Brief]

[6]. L Coscoy, et al. A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation. J Clin Invest. 2001 Jun;107(12):1599-606. [Content Brief]

[7]. Jaap D van Buul, et al. RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. J Cell Biol. 2007 Sep 24;178(7):1279-93. [Content Brief]

[8]. J Bella, et al. The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4140-5. [Content Brief]

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