Interferon regulatory factor 2-binding protein 2

Definition:

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles. Plays a role in immature B-cell differentiation.

References:

[1]. Kay S Childs, et al. Identification of novel co-repressor molecules for Interferon Regulatory Factor-2. Nucleic Acids Res. 2003 Jun 15;31(12):3016-26. [Content Brief]

[2]. Allen C T Teng, et al. IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression. FASEB J. 2010 Dec;24(12):4825-34. [Content Brief]

[3]. Michael D Keller, et al. Mutation in IRF2BP2 is responsible for a familial form of common variable immunodeficiency disorder. J Allergy Clin Immunol. 2016 Aug;138(2):544-550.e4. [Content Brief]

[4]. Flávia R G Carneiro, et al. Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity. Mol Cell Biol. 2011 Jul;31(14):2889-901. [Content Brief]

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