Interleukin-2 receptor subunit beta

Definition:

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.

References:

[1]. Isabel Z Fernandez, et al. A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019 Jun 3;216(6):1255-1267. [Content Brief]

[2]. Zinan Zhang, et al. Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance. J Exp Med. 2019 Jun 3;216(6):1311-1327. [Content Brief]

[3]. Claude Ratthé, et al. Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain. J Leukoc Biol. 2004 Jul;76(1):162-8. [Content Brief]

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