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  2. Interleukin-5 receptor subunit alpha

Interleukin-5 receptor subunit alpha

Definition:

Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming an heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway.

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