Intervertebral disc disease

Definition:

Intervertebral disk degeneration (IDD) is a common musculoskeletal disease associated with genetic factors.

References:

[1]. Donghua Huang, et al. Association of COL9A3 trp3 polymorphism with intervertebral disk degeneration: a meta-analysis. BMC Musculoskelet Disord. 2018 Oct 20;19(1):381. [Content Brief]

[2]. Futoshi Mio, et al. A functional polymorphism in COL11A1, which encodes the alpha 1 chain of type XI collagen, is associated with susceptibility to lumbar disc herniation. Am J Hum Genet. 2007 Dec;81(6):1271-7. [Content Brief]

[3]. Shoji Seki, et al. A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nat Genet. 2005 Jun;37(6):607-12. [Content Brief]

[4]. You-Qiang Song, et al. Association of the asporin D14 allele with lumbar-disc degeneration in Asians. Am J Hum Genet. 2008 Mar;82(3):744-7. [Content Brief]

[5]. Yuichiro Hirose, et al. A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. Am J Hum Genet. 2008 May;82(5):1122-9. [Content Brief]

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