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J774

Definition:

J774 is a mouse Macrophage-derived cancer cell line derived from Ascites and associated with Mouse reticulum cell sarcoma. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. J774 is used as an in vitro model of Mouse reticulum cell sarcoma to investigate inflammatory signaling.

References:

[1]. Yıldırım A, Özbilgin A, Yereli K. [Evaluation of Ex Vivo Cultivation Potentials of Trypanosoma cruzi, Leishmania tropica ve Toxoplasma gondii Parasites in J774, Vero and HeLa Cell Lines]. Mikrobiyoloji bulteni. 2023;57(1):71-82.

[2]. Khaliq HA, et al. Effect of a methanolic extract of Salvadora oleoides Decne. on LPS-activated J774 macrophages, its in vitro and in vivo toxicity study and dereplication of its chemical constituents. Toxicology reports. 2022;9:1742-1753.

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