Lamin-B1
Definition:
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
References:
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[1]. José Luiz Pedroso, et al. LMNB1 mutation causes cerebellar involvement and a genome instability defect. J Neurol Sci. 2017 Aug 15;379:249-252. [Content Brief]
[2]. Francesca Cristofoli, et al. De Novo Variants in LMNB1 Cause Pronounced Syndromic Microcephaly and Disruption of Nuclear Envelope Integrity. Am J Hum Genet. 2020 Oct 1;107(4):753-762. [Content Brief]
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