Leptin receptor gene-related protein
Definition:
Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
References:
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[1]. Thierry Touvier, et al. LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice. J Clin Invest. 2009 Dec;119(12):3830-8. [Content Brief]
[2]. Cyril Couturier, et al. Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19476-81. [Content Brief]
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