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LT12 tumor cell line

Definition:

LT12 tumor cell line is a rat cancer cell line and associated with Rat leukemia. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. LT12 tumor cell line is used as an in vitro model of Rat leukemia to investigate tumor-cell growth, cell survival, and pharmacological response.

References:

[1]. Lacaze N, Gombaud-Saintonge G, Lanotte M. Conditions controlling long-term proliferation of Brown Norway rat promyelocytic leukemia in vitro: primary growth stimulation by microenvironment and establishment of an autonomous Brown Norway 'leukemic stem cell line'. Leukemia research. 1983;7(2):145-54.

[2]. Arkesteijn GJ, et al. Bivariate flow karyotyping of acute myelocytic leukemia in the BNML rat model. Cytometry. 1987;8(6):618-24.

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