MAP/microtubule affinity-regulating kinase 3

Definition:

Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1.

References:

[1]. Julian Kwan, et al. DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Genes Dev. 2016 Dec 15;30(24):2696-2709. [Content Brief]

[2]. Jürgen Müller, et al. Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. EMBO J. 2003 Sep 1;22(17):4431-42. [Content Brief]

[3]. Gucci Jijuan Gu, et al. Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease. Neuromolecular Med. 2013 Sep;15(3):458-69. [Content Brief]

[4]. Franck Dequiedt, et al. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Mol Cell Biol. 2006 Oct;26(19):7086-102. [Content Brief]

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