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ME-180

Definition:

ME-180 is a human cancer cell line derived from Omentum and associated with Human papillomavirus-related cervical squamous cell carcinoma and Squamous cell carcinoma of the cervix uteri. ME-180 is immortalized or transformed by Human papillomavirus type 68 (HPV68). ME-180 is used as an in vitro model of Human papillomavirus-related cervical squamous cell carcinoma and Squamous cell carcinoma of the cervix uteri to investigate PI3K-AKT signaling, mTOR signaling, apoptosis, cell proliferation, and inflammatory signaling.

References:

[1]. Taguchi Y, Ito K, Kano F. PKM2 controls the translation of TFE3 to maintain the integrity of the Golgi apparatus for the survival of HeLa and ME-180 cervical cancer cells. The FEBS journal. 2023;290(12):3221-3242. [Content Brief]

[2]. Seshadri VD. Brucine promotes apoptosis in cervical cancer cells (ME-180) via suppression of inflammation and cell proliferation by regulating PI3K/AKT/mTOR signaling pathway. Environmental toxicology. 2021;36(9):1841-1847.

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