Melioidosis

Definition:

Melioidosis (MD) is an infection caused by the gram-negative soil-dwelling bacillus Burkholderia pseudomallei. It predominantly affects people in regular contact with soil and water and is endemic in areas of Southeast Asia and Northern Australia. There are many possible disease manifestations including melioidosis septic shock, pneumonia, and hepatic and splenic abscesses.

References:

[1]. Direk Limmathurotsakul, et al. Melioidosis: a clinical overview. Br Med Bull. 2011;99:125-39. [Content Brief]

[2]. T Eoin West, et al. Impaired TLR5 functionality is associated with survival in melioidosis. J Immunol. 2013 Apr 1;190(7):3373-9. [Content Brief]

[3]. W Joost Wiersinga, et al. Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei. Nat Rev Microbiol. 2006 Apr;4(4):272-82. [Content Brief]

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