Membrane progestin receptor delta

Definition:

Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. Involved in neurosteroid inhibition of apoptosis. May be involved in regulating rapid P4 signaling in the nervous system. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone.

References:

[1]. Yefei Pang, et al. Characterization, neurosteroid binding and brain distribution of human membrane progesterone receptors δ and {epsilon} (mPRδ and mPR{epsilon}) and mPRδ involvement in neurosteroid inhibition of apoptosis. Endocrinology. 2013 Jan;154(1):283-95. [Content Brief]

[2]. S L Petersen, et al. Nonclassical progesterone signalling molecules in the nervous system. J Neuroendocrinol. 2013 Nov;25(11):991-1001. [Content Brief]

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