Mini-chromosome maintenance complex-binding protein

Definition:

Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.

References:

[1]. Atsuya Nishiyama, et al. MCM-BP regulates unloading of the MCM2-7 helicase in late S phase. Genes Dev. 2011 Jan 15;25(2):165-75. [Content Brief]

[2]. Naoki Takahashi, et al. The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. PLoS Genet. 2010 Jan 15;6(1):e1000817. [Content Brief]

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