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Mitofusin-1

Definition:

Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coiled coil domains. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity.

References:

[1]. Yuanbo Qi, et al. Structures of human mitofusin 1 provide insight into mitochondrial tethering. J Cell Biol. 2016 Dec 5;215(5):621-629. [Content Brief]

[2]. Yu-Lu Cao, et al. MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion. Nature. 2017 Feb 16;542(7641):372-376. [Content Brief]

[3]. Ansgar Santel, et al. Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. J Cell Sci. 2003 Jul 1;116(Pt 13):2763-74. [Content Brief]

[4]. Frédéric Legros, et al. Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Mol Biol Cell. 2002 Dec;13(12):4343-54. [Content Brief]

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