Mitotic interactor and substrate of PLK1
Definition:
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.
References:
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[1]. Mei Zhu, et al. MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression. J Cell Biol. 2013 Mar 18;200(6):773-87. [Content Brief]
[2]. Bettina Maier, et al. The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. Cell Cycle. 2013 May 1;12(9):1457-71. [Content Brief]
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