MPN domain-containing protein

Definition:

Probable protease (By similarity). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation.

References:

[1]. Soo-Mi Kweon, et al. An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing. Mol Cell. 2019 Jun 20;74(6):1138-1147.e6. [Content Brief]

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