MRN complex-interacting protein

Definition:

Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair.

References:

[1]. Christopher J Staples, et al. MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response. Cell Rep. 2016 Sep 6;16(10):2565-2575. [Content Brief]

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