mRNA-capping enzyme

Definition:

Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.

References:

[1]. T Yamada-Okabe, et al. Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme. Nucleic Acids Res. 1998 Apr 1;26(7):1700-6. [Content Brief]

[2]. Chun Chu, et al. Structure of the guanylyltransferase domain of human mRNA capping enzyme. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10104-8. [Content Brief]

[3]. T Tsukamoto, et al. Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme. Biochem Biophys Res Commun. 1998 Feb 4;243(1):101-8. [Content Brief]

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