mRNA export factor RAE1

Definition:

Acts as mRNA export factor involved in nucleocytoplasmic transport. Plays a role in mitotic bipolar spindle formation. May function in attaching cytoplasmic mRNPs to the cytoskeleton both directly or indirectly.

References:

[1]. Richard W Wong, et al. Rae1 interaction with NuMA is required for bipolar spindle formation. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19783-7. [Content Brief]

[2]. Amin Addetia, et al. SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98. mBio. 2021 Apr 13;12(2):e00065-21. [Content Brief]

[3]. Yi Ren, et al. Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10406-11. [Content Brief]

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