Multivesicular body subunit 12A

Definition:

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.

References:

[1]. Hiroaki Konishi, et al. CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP. J Biol Chem. 2006 Sep 29;281(39):28919-31. [Content Brief]

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