Myc box-dependent-interacting protein 1

Definition:

Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro.

References:

[1]. Nina M Dräger, et al. Bin1 directly remodels actin dynamics through its BAR domain. EMBO Rep. 2017 Nov;18(11):2051-2066. [Content Brief]

[2]. D Sakamuro, et al. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet. 1996 Sep;14(1):69-77. [Content Brief]

[3]. Toji Miyagawa, et al. BIN1 regulates BACE1 intracellular trafficking and amyloid-β production. Hum Mol Genet. 2016 Jul 15;25(14):2948-2958. [Content Brief]

[4]. Tingting Wu, et al. Mutations in BIN1 associated with centronuclear myopathy disrupt membrane remodeling by affecting protein density and oligomerization. PLoS One. 2014 Apr 22;9(4):e93060. [Content Brief]

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