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NCI-H1650

Definition:

NCI-H1650 is a human cancer cell line derived from Pleural effusion and associated with Minimally invasive lung adenocarcinoma. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. NCI-H1650 is used as an in vitro model of Minimally invasive lung adenocarcinoma to investigate mTOR signaling, apoptosis, cell proliferation, and cell-cycle control.

References:

[1]. Li L, et al. β-elemene suppresses Warburg effect in NCI-H1650 non-small-cell lung cancer cells by regulating the miR-301a-3p/AMPKα axis. Bioscience reports. 2020;40(6).

[2]. Xu X, et al. Silencing the FOLR2 Gene Inhibits Cell Proliferation and Increases Apoptosis in the NCI-H1650 Non-Small Cell Lung Cancer Cell Line via Inhibition of AKT/Mammalian Target of Rapamycin (mTOR)/Ribosomal Protein S6 Kinase 1 (S6K1) Signaling. Medical science monitor : international medical journal of experimental and clinical research. 2018;24:8064-8073.

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