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NCI-H295R

Definition:

NCI-H295R is a human cancer cell line derived from Adrenal gland and associated with Adrenal cortex carcinoma and Adrenocortical carcinoma. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. NCI-H295R is used as an in vitro model of Adrenal cortex carcinoma and Adrenocortical carcinoma to investigate tumor-cell growth, cell survival, and pharmacological response.

References:

[1]. Samandari E, et al. Human adrenal corticocarcinoma NCI-H295R cells produce more androgens than NCI-H295A cells and differ in 3beta-hydroxysteroid dehydrogenase type 2 and 17,20 lyase activities. The Journal of endocrinology. 2007;195(3):459-72.

[2]. Nishi H, Arai H, Momiyama T. NCI-H295R, a human adrenal cortex-derived cell line, expresses purinergic receptors linked to Ca²⁺-mobilization/influx and cortisol secretion. PloS one. 2013;8(8):e71022. [Content Brief]

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