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NCI-H322M

Definition:

NCI-H322M is a human Club cell-derived cancer cell line derived from Lung and associated with Minimally invasive lung adenocarcinoma. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. NCI-H322M is used as an in vitro model of Minimally invasive lung adenocarcinoma to investigate tumor-cell growth, cell survival, and pharmacological response.

References:

[1]. O'Connor PM, et al. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer research. 1997;57(19):4285-300.

[2]. Ross DT, et al. Systematic variation in gene expression patterns in human cancer cell lines. Nature genetics. 2000;24(3):227-35. [Content Brief]

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