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NCI-H446

Definition:

NCI-H446 is a human cancer cell line derived from Pleural effusion and associated with Lung small cell carcinoma and Small cell lung cancer. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. NCI-H446 is used as an in vitro model of Lung small cell carcinoma and Small cell lung cancer to investigate apoptosis, cell proliferation, cell-cycle control, and cytotoxicity.

References:

[1]. Wei L, et al. Per- and polyfluoroalkyl substances induce cytotoxicity in NCI-H446 cells through modulating proliferation, apoptosis, and m6A methylation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2026;208:115868.

[2]. Ding JY, et al. Effects of three IL-15 variants on NCI-H446 cell proliferation and expression of cell cycle regulatory molecules. Oncotarget. 2017;8(64):108108-108117.

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