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NCI-H460

Definition:

NCI-H460 is a human cancer cell line derived from Pleural effusion and associated with Lung large cell carcinoma. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. NCI-H460 is used as an in vitro model of Lung large cell carcinoma to investigate Wnt signaling.

References:

[1]. Chen C, Zhang W. Itraconazole Alters the Stem Cell Characteristics of A549 and NCI-H460 Human Lung Cancer Cells by Suppressing Wnt Signaling. Medical science monitor : international medical journal of experimental and clinical research. 2019;25:9509-9516. [Content Brief]

[2]. Townsend MH, et al. Non-small-cell lung cancer cell lines A549 and NCI-H460 express hypoxanthine guanine phosphoribosyltransferase on the plasma membrane. OncoTargets and therapy. 2017;10:1921-1932.

Biomedical Dictionary

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