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NCI-H596

Definition:

NCI-H596 is a human cancer cell line derived from Lung and associated with Lung adenosquamous carcinoma. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. NCI-H596 is used as an in vitro model of Lung adenosquamous carcinoma to investigate p53 signaling and EGFR signaling.

References:

[1]. Xu X, Yang G, Shi N. Ceritinib Reduces Transendothelial Invasion of Non-small Cell Lung Cancer Cells by Restoring Claudin-10 and Suppressing VEGF-A Signaling. Biochemical genetics. 2026;64(2):1725-1743. [Content Brief]

[2]. Nakamichi S, et al. SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer. Carcinogenesis. 2025;46(4).

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