Neuronal regeneration-related protein
Definition:
May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.
References:
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[1]. Wendy S McDonough, et al. Regulation of glioma cell migration by serine-phosphorylated P311. Neoplasia. 2005 Sep;7(9):862-72. [Content Brief]
[2]. L Mariani, et al. Identification and validation of P311 as a glioblastoma invasion gene using laser capture microdissection. Cancer Res. 2001 May 15;61(10):4190-6. [Content Brief]
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