Nuclear nucleic acid-binding protein C1D

Definition:

Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).

References:

[1]. U Yavuzer, et al. DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. Genes Dev. 1998 Jul 15;12(14):2188-99. [Content Brief]

[2]. K Rothbarth, et al. Induction of apoptosis by overexpression of the DNA-binding and DNA-PK-activating protein C1D. J Cell Sci. 1999 Jul;112 ( Pt 13):2223-32. [Content Brief]

[3]. Geurt Schilders, et al. C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. Nucleic Acids Res. 2007;35(8):2564-72. [Content Brief]

[4]. Tuba Erdemir, et al. DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). J Cell Sci. 2002 Jan 1;115(Pt 1):207-16. [Content Brief]

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