Nucleolar protein 58

Definition:

Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs.

References:

[1]. Kenneth Scott McKeegan, et al. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. Mol Cell Biol. 2007 Oct;27(19):6782-93. [Content Brief]

[2]. Nicholas J Watkins, et al. Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex. Mol Cell. 2004 Dec 3;16(5):789-98. [Content Brief]

[3]. Kenneth Scott McKeegan, et al. Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis. Mol Cell Biol. 2009 Sep;29(18):4971-81. [Content Brief]

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