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OCI-AML2

Definition:

OCI-AML2 is a human cancer cell line derived from Peripheral blood and associated with Adult acute myeloid leukemia and q23) KMT2A-MLLT4. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. OCI-AML2 is used as an in vitro model of Adult acute myeloid leukemia and q23) KMT2A-MLLT4 to investigate tumor-cell growth, cell survival, and pharmacological response.

References:

[1]. Andersson A, et al. Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations. Leukemia. 2005;19(6):1042-50.

[2]. Quentmeier H, et al. JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders. Leukemia. 2006;20(3):471-6.

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