Osteocrin

Definition:

Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience. Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex. Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).

References:

[1]. Bulent Ataman, et al. Evolution of Osteocrin as an activity-regulated factor in the primate brain. Nature. 2016 Nov 10;539(7628):242-247. [Content Brief]

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