Patatin-like phospholipase domain-containing protein 6
Definition:
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids. Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides.
References:
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[1]. Marianne van Tienhoven, et al. Human neuropathy target esterase catalyzes hydrolysis of membrane lipids. J Biol Chem. 2002 Jun 7;277(23):20942-8. [Content Brief]
[2]. Oliver Zaccheo, et al. Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells. J Biol Chem. 2004 Jun 4;279(23):24024-33. [Content Brief]
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