PH domain leucine-rich repeat-containing protein phosphatase 2
Definition:
References:
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[1]. Meng Qiao, et al. Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis. Mol Cell. 2010 May 28;38(4):512-23. [Content Brief]
[2]. Tianyan Gao, et al. The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem. 2008 Mar 7;283(10):6300-11. [Content Brief]
[3]. J Liu, et al. Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. Oncogene. 2009 Feb 19;28(7):994-1004. [Content Brief]
[4]. Jianyu Liu, et al. PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth. Mol Cell Biol. 2011 Dec;31(24):4917-27. [Content Brief]
[5]. John Brognard, et al. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell. 2007 Mar 23;25(6):917-31. [Content Brief]
[6]. Xin Li, et al. PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice. Gastroenterology. 2014 May;146(5):1301-12.e1-10. [Content Brief]
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