Phosphatidylcholine-sterol acyltransferase
Definition:
References:
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[1]. Yue Zhao, et al. Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains. Biochemistry. 2003 Dec 2;42(47):13941-9. [Content Brief]
[2]. Derek E Piper, et al. The high-resolution crystal structure of human LCAT. J Lipid Res. 2015 Sep;56(9):1711-9. [Content Brief]
[3]. Junken Aoki, et al. Serum lysophosphatidic acid is produced through diverse phospholipase pathways. J Biol Chem. 2002 Dec 13;277(50):48737-44. [Content Brief]
[4]. Veronica Hirsch-Reinshagen, et al. LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins. J Lipid Res. 2009 May;50(5):885-93. [Content Brief]
[5]. A B Kosek, et al. Binding affinity and reactivity of lecithin cholesterol acyltransferase with native lipoproteins. Biochem Biophys Res Commun. 1999 May 19;258(3):548-51. [Content Brief]
[6]. M Liu, et al. Hydrolysis and transesterification of platelet-activating factor by lecithin-cholesterol acyltransferase. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6035-9. [Content Brief]
[7]. Valeria La Marca, et al. The enzyme lecithin-cholesterol acyltransferase esterifies cerebrosterol and limits the toxic effect of this oxysterol on SH-SY5Y cells. J Neurochem. 2014 Jul;130(1):97-108. [Content Brief]
[8]. M A Clay, et al. Formation of spherical, reconstituted high density lipoproteins containing both apolipoproteins A-I and A-II is mediated by lecithin:cholesterol acyltransferase. J Biol Chem. 2000 Mar 24;275(12):9019-25. [Content Brief]
[9]. P V Subbaiah, et al. Comparative studies on the substrate specificity of lecithin:cholesterol acyltransferase towards the molecular species of phosphatidylcholine in the plasma of 14 vertebrates. J Lipid Res. 1996 Jan;37(1):113-22. [Content Brief]
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