POC1 centriolar protein homolog A

Definition

Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation.

References:

[1]. Magali Venoux, et al. Poc1A and Poc1B act together in human cells to ensure centriole integrity. J Cell Sci. 2013 Jan 1;126(Pt 1):163-75. [Content Brief]

[2]. Lani C Keller, et al. Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control. Mol Biol Cell. 2009 Feb;20(4):1150-66. [Content Brief]

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