Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Definition

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.

References:

[1]. Chia-Hsueh Lee, et al. Structures of the Human HCN1 Hyperpolarization-Activated Channel. Cell. 2017 Jan 12;168(1-2):111-120.e11. [Content Brief]

[2]. Catherine H Gill, et al. Characterization of the human HCN1 channel and its inhibition by capsazepine. Br J Pharmacol. 2004 Oct;143(3):411-21. [Content Brief]

[3]. Carla Marini, et al. HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond. Brain. 2018 Nov 1;141(11):3160-3178. [Content Brief]

[4]. Mattia Bonzanni, et al. A novel de novo HCN1 loss-of-function mutation in genetic generalized epilepsy causing increased neuronal excitability. Neurobiol Dis. 2018 Oct;118:55-63. [Content Brief]

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