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Prostasin

Definition:

Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).

References:

[1]. Aaron Shipway, et al. Biochemical characterization of prostasin, a channel activating protease. Biochem Biophys Res Commun. 2004 Nov 12;324(2):953-63. [Content Brief]

[2]. Zhenyue Tong, et al. Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line. Am J Physiol Lung Cell Mol Physiol. 2004 Nov;287(5):L928-35. [Content Brief]

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