Protein cereblon
Definition:
References:
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[1]. Anita K Gandhi, et al. Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.). Br J Haematol. 2014 Mar;164(6):811-21. [Content Brief]
[2]. Takumi Ito, et al. Identification of a primary target of thalidomide teratogenicity. Science. 2010 Mar 12;327(5971):1345-50. [Content Brief]
[3]. Eric S Fischer, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [Content Brief]
[4]. Tae-Yong Choi, et al. Cereblon Maintains Synaptic and Cognitive Function by Regulating BK Channel. J Neurosci. 2018 Apr 4;38(14):3571-3583. [Content Brief]
[5]. Qihui Lian, et al. Cereblon Promotes the Ubiquitination and Proteasomal Degradation of Interleukin Enhancer-Binding Factor 2. Protein J. 2020 Oct;39(5):411-421. [Content Brief]
[6]. Philip P Chamberlain, et al. Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nat Struct Mol Biol. 2014 Sep;21(9):803-9. [Content Brief]
[7]. Joseph J Higgins, et al. Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation. Neurogenetics. 2008 Jul;9(3):219-23. [Content Brief]
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