Protein CREG1
Definition:
May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.
References:
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[1]. E Veal, et al. A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. Mol Cell Biol. 1998 Sep;18(9):5032-41. [Content Brief]
[2]. Alessandra Di Bacco, et al. The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor. Oncogene. 2003 Aug 21;22(35):5436-45. [Content Brief]
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