PT-45
Definition:
PT-45 is a human cancer cell line derived from Pancreas and associated with Pancreatic ductal adenocarcinoma. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. PT-45 is used as an in vitro model of Pancreatic ductal adenocarcinoma to investigate tumor-cell growth, cell survival, and pharmacological response.
References:
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[1]. Pilarsky C, et al. Activation of Wnt signalling in stroma from pancreatic cancer identified by gene expression profiling. Journal of cellular and molecular medicine. 2008;12(6B):2823-35. [Content Brief]
[2]. Barton CM, et al. Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer. British journal of cancer. 1991;64(6):1076-82. [Content Brief]
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